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KMID : 0848020030060040277
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Journal of Korean Breast Cancer Society
2003 Volume.6 No. 4 p.277 ~ p.282
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Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast
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송혁/Song H
구태영/박지훈/송기학/김성태/최인석/최원준/목우균/민현식/윤대성/Koo TY/Park JH/Song KH/Kim ST/Choi IS/Choi WJ/Mok WK/Min HS/Yoon DS
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Abstract
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Purpose: The isoflavones in soy are likely to contribute to the historically low incidence of breast cancer among Asian women that consume traditional diets. A possible role of isoflavones in controlling the expression of cyclooxygenase-2 (Cox-2) has not previously been explored. In this study, the ability of the isoflavone, genistein, to regulate the expression of Cox-2 in breast cancer cells was evaluated.
Methods:The effects of genistein and NS-398, a Cox-2 inhibitor, were examined on the expression of Cox-2 at the mRNA level using the MDA-MB 231, and MCF-7 breast cancer cell-lines.
Results: In the MCF-7 cells, the Cox-2 mRNA could not be detected using RT-PCR. In the MDA-MB-231 cells, NS-398 and genistein were found to inhibit the Cox-2 mRNA expressions by 50 and 35∼40%, respectively.
Conclusion: These studies suggest that dietary isoflavonoids may contribute to the prevention or inhibition of breast cancer by inhibiting the Cox-2 expression. (Journal of Korean Breast Cancer Society 2003;6:277-282)
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